That Fatal Sneeze (1907)

As an older man and a youth are eating at the table, the older man decides to amuse himself by using pepper to make the boy sneeze. Later, the boy retaliates by sneaking into the older man's room and putting pepper in his handkerchief, hairbrush, and clothing. But things quickly get out of hand when the sneezing that results begins to disrupt the whole town.

Comedy, Science Fiction